2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-138104
    SL-164 3476-88-8 98%
    SL-164 is a quinazolinone. SL-164 has sedative properties.
    SL-164
  • HY-138257
    (S)-Indeloxazine benzenesulfonate 1214994-13-4 98%
    (S)-AS1069562 is the S-enantiomer of AS1069562 (HY-138257A). AS1069562 is an orally active 5-HT and NE reuptake inhibitor, with IC50 values of 0.35 μM and 3.3 μM, respectively. AS1069562 possesses curative-like analgesic effect. AS1069562 might improve nerve function impairment via the amelioration of neurotrophic support.
    (S)-Indeloxazine benzenesulfonate
  • HY-138679
    Aberrant tau ligand 2 2417159-58-9 98%
    Aberrant tau ligand 2 (Compound 4-12) is the ligand for tau protein and can be used as target protein ligand for synthesis of PROTAC degrader C004019 (HY-138669).
    Aberrant tau ligand 2
  • HY-138806
    PAQ 943902-10-1 98%
    PAQ (Compound 4c) is a quinoxaline derivative. PAQ is an orally active neuroprotective agent, which targets dopamine (DA) neurons and activates reticulum endoplasmic ryanodine receptor (RyR) channels, without effects on glia cells.
    PAQ
  • HY-138809
    FAUC 346 474432-65-0 99.90%
    FAUC 346, a highly selective D3 partial agonist (EC50 = 1.5 nM).
    FAUC 346
  • HY-138816
    Nav1.7-IN-15 1356834-62-2 98%
    Nav1.7-IN-15 (Compd 9) is a potent and state-dependent Nav1.7 antagonist, with an IC50 of 0.42 μM for hNav1.7 PX.
    Nav1.7-IN-15
  • HY-138839
    Allyphenyline oxalate 1092984-08-1 98%
    Allyphenyline oxalate (compound 9) can enhance the analgesic effect of Morphine. The pKi values ​​of Allyphenyline for α2A, α2B and α2C are 7.24, 6.47 and 7.07, respectively.
    Allyphenyline oxalate
  • HY-138906
    25C-NBF hydrochloride 1539266-21-1 98%
    25C-NBF hydrochloride is an agonist of 5-HT receptors that activates 5-HT2A and 5-HT2C similarly (EC50s = ~0.3 μM for each).
    25C-NBF hydrochloride
  • HY-138940
    3-Methoxy PCE hydrochloride 1797121-52-8 98%
    3-Methoxy PCE (3-MEO PCE) hydrochloride is structurally classified as an arylcyclohexylamine and is an /b>NMDA receptor antagonist with a pKi value of 7.22.
    3-Methoxy PCE hydrochloride
  • HY-138953
    Epiboxidine 188895-96-7 98%
    Epiboxidine is a potent and selective neural nAChR agonist with Kis of 0.46 nM and 1.2 nM for rat and human α4β2 nAChRs, respectively. Epiboxidine is a methylisoxazole analog of the alkaloid Epibatidine, and is also an analog of another nAChR agonist, ABT 418.
    Epiboxidine
  • HY-138967
    BRF110 2095489-35-1 98%
    BRF110 is the selective, orally active rexinoid for Nurr1-RXRα, that selectively activates the Nurr1-RXRα heterodimer with an EC50 of 0.9 μM in SH-SY5Y. BRF110 upregulates the expression of BDNF, exhibits neuroprotective activity against MPP+ induced toxicity. BRF110 can cross blood-brain barrier.
    BRF110
  • HY-138984
    GRT2932Q 228246-34-2 98%
    GRT2932Q is a nonpeptidic opioid receptor-like 1 (ORL1) agonist.
    GRT2932Q
  • HY-139006
    N-Oleoyl glutamine 247150-73-8 98%
    N-oleoyl-glutamine is a PM20D1-regulated N-acyl amino acids (NAAs). N-oleoyl-glutamine is a transient receptor potential (TRP) antagonist.
    N-Oleoyl glutamine
  • HY-139052
    III-31-C 398515-96-3 98%
    III-31-C is a (hydroxyethyl)urea γ-secretase inhibitor. III-31-C inhibits Aऔ production with an IC50 of 10 nM in the cell-free γ-secretase assay and 200 nM in APP-transfected cells. III-31-C can be used in Alzheimer's disease research.
    III-31-C
  • HY-139088
    PAD3-IN-1 1671088-84-8 98%
    PAD3-IN-1 (compound 14b) is an inhibitor of protein arginine deiminase (PAD) and is more than 10-fold more selective for PAD3 than PAD 1, 2, and 4. The IC50 values ​​of PAD3-IN-1 for PAD 1, 2, 3, and 4 are 120, 27.5, 4.5, and 30.5 μM, respectively. And PAD3 is a PAD isoform associated with neurodegenerative responses to spinal cord injury, and PAD3-IN-1 could be used to study PAD-related neurological diseases.
    PAD3-IN-1
  • HY-139126
    (±)-Muscarine chloride 2936-25-6 98%
    (±)-Muscarine chloride is the racemate of Muscarine chloride. Muscarine is a prototype muscarinic acetylcholine receptor agonist.
    (±)-Muscarine chloride
  • HY-139144
    YM-08 812647-88-4 98%
    YM-08 (Compounds 7a) is a brain-penetrant inhibitors of SIRT2,with the IC50 of 19.9 μM. YM-08 also is inhibitor of Hsp70.
    YM-08
  • HY-139145
    Etbicyphat 1005-93-2 ≥98.0%
    Etbicyphat (Trimethylopropane phosphate) is a potent GABA(A) receptors competitive antagonist. Etbicyphat induces epileptiform activities in hippocampal CA1 neurons, and binds to the GABA(A)-benzodiazepine receptors.
    Etbicyphat
  • HY-139233
    25P-NBOMe hydrochloride 1539266-43-7 98%
    25P-NBOMe hydrochloride is structurally categorized as a phenethylamine. 25P-NBOMe hydrochloride binds 5-HT receptors 5-HT2A and 5-HT2C with similar affinities.
    25P-NBOMe hydrochloride
  • HY-13929R
    Isocarboxazid (Standard) 59-63-2
    Isocarboxazid (Standard) is the analytical standard of Isocarboxazid. This product is intended for research and analytical applications. Isocarboxazid is a non-selective and irreversible inhibitor of monoamine oxidase, with an IC50 of 4.8 μM for rat brain monoamine oxidase in vitro.
    Isocarboxazid (Standard)
Cat. No. Product Name / Synonyms Application Reactivity